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estimated treatment difference [ETD] range 3.07.8%

Peripheral tissues like skin (high turnover rates, moderate mitochondrial capacity) are particularly vulnerable

Treatment with Fer-1, Lip-1, or neural stem cell-derived extracellular vesicles enriched in CDC42 substantially attenuates cerebrovascular damage and cognitive deficits in PD mice ( + treatment significantly reduces TIGAR expression in HT22 cells, downregulates NADPH, GPX4, and GSH levels, upregulates GSSG levels and the GSSG/GSH ratio, decreases adenosine triphosphate (ATP) production, and promotes neuronal ferroptosis, iron-dependent lipid peroxidation, and mitochondrial dysfunction, thereby exacerbating neuronal cytotoxicity

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